问题描述：
英语翻译
Naltrexone,an orally effective,long-lasting opiate receptor
antagonist,was approved by the FDA for treating alcohol and opiate
addiction in 1984,but its general patent expired the following
year.It is a non-selective antagonist,with robust effects on pleasure
promoting mu opioid receptors (MOR) and delta opioid receptors
(DOR) [1],with less antagonism of aversion-mediating kappa
opioid receptors (KOR) [2] but substantial effect on the more recently
discovered orphanin FQ or nociceptin [N/OFQ] opioid family
[3].The benefits of high dose naltrexone in narcotic addiction are
explained by blockade of all pleasure producing effects of opioids,
and similar mechanisms may explain the ability of naltrexone to
reduce binging on alcohol.
Naltrexone,an orally effective,long-lasting opiate receptor
antagonist,was approved by the FDA for treating alcohol and opiate
addiction in 1984,but its general patent expired the following
year.It is a non-selective antagonist,with robust effects on pleasure
promoting mu opioid receptors (MOR) and delta opioid receptors
(DOR) [1],with less antagonism of aversion-mediating kappa
opioid receptors (KOR) [2] but substantial effect on the more recently
discovered orphanin FQ or nociceptin [N/OFQ] opioid family
[3].The benefits of high dose naltrexone in narcotic addiction are
explained by blockade of all pleasure producing effects of opioids,
and similar mechanisms may explain the ability of naltrexone to
reduce binging on alcohol.
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