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英语翻译
Clinical Studies
While there have been many trials that have reported the effectiveness of roxithromycin in treating various parasitic and bacterial infections,these have mostly been in non-HIV+ people.In HIV+ people,two trials have been completed to determine the effect of roxithromycin on cryptosporidiosis.However,both of these trials are small and uncontrolled.We hope that roxithromycin will be studied in HIV+ people,in a larger,controlled trial for cryptosporidiosis.Roxithromycin and cryptosporidiosis:At the 1994 International Conference on AIDS in Japan,results from a nine person study being treated for AIDS-related cryptosporidiosis were announced.Each of the PWAs received one 300 mg tablet,twice daily,for 4 weeks.After 2 weeks,complete clearance (no diarrhea,negative cryptosporidium stood cultures) were reported in 5 participants.A partial response (diarrhea improvement and decreased cryptosporidium culture) was reported in 3 participants,with no improvement reported in one participant.An earlier,even smaller trial of roxithromycin reported significant response in four participants.In this trial,four PWAs also took 300 mg of roxithromycin,twice daily,for two weeks.All participants were successfully treated for diarrhea,with improvements being reported in as little as two days upon starting treatment.Upon completion of the trial,3 of the 4 participants were negative for cryptosporidium cultures.While the remaining participant showed initial diarrhea remission,it had recurred after the treatment ended.
Clinical Studies
While there have been many trials that have reported the effectiveness of roxithromycin in treating various parasitic and bacterial infections,these have mostly been in non-HIV+ people.In HIV+ people,two trials have been completed to determine the effect of roxithromycin on cryptosporidiosis.However,both of these trials are small and uncontrolled.We hope that roxithromycin will be studied in HIV+ people,in a larger,controlled trial for cryptosporidiosis.Roxithromycin and cryptosporidiosis:At the 1994 International Conference on AIDS in Japan,results from a nine person study being treated for AIDS-related cryptosporidiosis were announced.Each of the PWAs received one 300 mg tablet,twice daily,for 4 weeks.After 2 weeks,complete clearance (no diarrhea,negative cryptosporidium stood cultures) were reported in 5 participants.A partial response (diarrhea improvement and decreased cryptosporidium culture) was reported in 3 participants,with no improvement reported in one participant.An earlier,even smaller trial of roxithromycin reported significant response in four participants.In this trial,four PWAs also took 300 mg of roxithromycin,twice daily,for two weeks.All participants were successfully treated for diarrhea,with improvements being reported in as little as two days upon starting treatment.Upon completion of the trial,3 of the 4 participants were negative for cryptosporidium cultures.While the remaining participant showed initial diarrhea remission,it had recurred after the treatment ended.
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