what's wrong?what's up?what's happend?what's the matter?有什么区

what's wrong? 大致发生了不大对头的事情
what's up? 一般地询问发生了什么大家感兴趣的事情
what's happend? 大概发生过什么事情
what's the matter?带有责备的口气
看你用在哪儿啰!