问题描述:
英语翻译
The great variety of human cell types in morphology
and function is due to the diverse gene expression profiles that
are governed by the distinctive regulatory networks in different cell
types.It is still a challenging task to explain how the regulatory
networks achieve the diversity of different cell types.Here,we report
on our studies of the design principles of the tissue regulatory system
by constructing the regulatory networks of eight human tissues,
which subsume the regulatory interactions between transcription
factors (TFs),microRNAs (miRNAs) and non-TF target genes.
The great variety of human cell types in morphology
and function is due to the diverse gene expression profiles that
are governed by the distinctive regulatory networks in different cell
types.It is still a challenging task to explain how the regulatory
networks achieve the diversity of different cell types.Here,we report
on our studies of the design principles of the tissue regulatory system
by constructing the regulatory networks of eight human tissues,
which subsume the regulatory interactions between transcription
factors (TFs),microRNAs (miRNAs) and non-TF target genes.
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