问题描述：
英语翻译
Recurring cycles of cellular growth and division present a simple
question:how do cells link these processes and divide only upon
reaching an appropriate size?Genetic screens have identified com-
ponents in the fission yeast controlling cell size at division6,7
.The
central factor Cdk1 drives entry into mitosis by phosphorylating a
wide range of targets
8
.In small cells that are in early G2,Cdk1 is kept
inactive by the kinaseWee1,which directly phosphorylates and inhi-
bits Cdk1.As cell size increases during G2,the phosphatase Cdc25
removes this inhibitory phosphorylation to activate Cdk1 and allow
mitotic entry.Thus,the mitotic entry control system coordinates a
balance of Wee1 and Cdc25 activity with changes in cell size to
generate a reproducible cell size at division.Although several factors
regulating Wee1 and Cdc25 have been identified3
,the links between
cell size and the Wee1-Cdc25-Cdk1 module have remained elusive.
Recurring cycles of cellular growth and division present a simple
question:how do cells link these processes and divide only upon
reaching an appropriate size?Genetic screens have identified com-
ponents in the fission yeast controlling cell size at division6,7
.The
central factor Cdk1 drives entry into mitosis by phosphorylating a
wide range of targets
8
.In small cells that are in early G2,Cdk1 is kept
inactive by the kinaseWee1,which directly phosphorylates and inhi-
bits Cdk1.As cell size increases during G2,the phosphatase Cdc25
removes this inhibitory phosphorylation to activate Cdk1 and allow
mitotic entry.Thus,the mitotic entry control system coordinates a
balance of Wee1 and Cdc25 activity with changes in cell size to
generate a reproducible cell size at division.Although several factors
regulating Wee1 and Cdc25 have been identified3
,the links between
cell size and the Wee1-Cdc25-Cdk1 module have remained elusive.
问题解答：
我来补答展开全文阅读