Much effort ----she had made,she still failed to pass the dr

as,though ,although这三个词的用法各有区别.
1.as 引导的让步状语从句必须倒装;
2.though 引导的让步状语从句可以倒装也可以不倒装;
3.although引导的让步状语从句不能倒装.
1)Nice as he is ,I dislike him .(必须倒装）
2)Though he is nice ,I dislike him .(可不倒装）
2)Nice though he is ,I dislike him.(可倒装）
3)Although he is nice ,I dislike him .(不能倒装）
所以第一题选 as/though 都对.
第二题句子本身有问题,关系代词指代的是不定代词"nothing"应该用"makes"
如仍有疑问,请听听自己老师的解释吧.