英语翻译9-(2-Methylphenyl)-3,4,5,6,9,10-hexahydroxanthene-1,8(2H

英语翻译
9-(2-Methylphenyl)-3,4,5,6,9,10-hexahydroxanthene-
1,8(2H,7H)-dione
Marco Brito-Arias,(1) Manuel Tapia-Albarra´ n,(1) Itzia Padilla-Martı´nez,(1) Francisco
Martı´nez-Martı´nez,(1) Georgina Espinosa,(2) Elies Molins,(3)* and Enrique Espinosa
Experimental section
Our general approach uses 1,3-cyclohexanedione
(1) and ortho substituted benzaldehydes (2a–d)
as starting materials,which were condensed with
KOH in EtOHUH2O media to generate intermediate
(3),which is further reacted with sodium methoxide
solution at room temperature to afford (4).This
reaction can also be carried out straightforwardly by
reacting (1) and (2) with sodium methoxide solution
to directly produce (4) in 60% yield.The 1H NMR
spectroscopy displays similar signal pattern in
agreement with the X-ray structure obtained.Thus,
for (4b) (CDCl3):d 2.0 (4H,t),2.3 (4H,m),2.7 (4H,
t),2.9 (3H,s),5.0 (1H,s),7.0–7.6 (4H,m).It is
noteworthy to mention that the dimeric intermediate
(3),which we have been able to isolate,is a key
intermediate for the preparation of the heterocyclic
three ring systems (4),(5),and (6) that we have reported
so far.Therefore,depending on the system
requested (either the xanthendione (4),the acridindione
(5),or the acridone (6) derivatives),the intermediate
(3) must be treated with sodium methoxide
solution,with amines or sodium azide,and with iron
in acid,respectively.
The structure of the title compound was solved
by direct methods.Refinement was based on fullmatrix
least-squares methods,with anisotropic displacement
parameters for all non-H atoms and a
global fixed isotropic displacement parameter for H
atoms.Hatoms were included at calculated positions,
using a riding model.Table 1 shows crystal data and
the structure refinement parameters corresponding
to the x-ray diffraction analysis.