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英语翻译
Other ComX pheromones—such as ComX168 and ComXRO-C-2,produced by strains 168 and RO-C-2 of B.subtilis,respectively—are predicted to be modified by farnesyl groups,based on the mass of their modifications1,2.Given the role of ComQ in the isoprenylation of each ComX variant5,the structures of these pheromones may be similar to that described here.Early work on the farnesyl modification of the C-terminal cysteine in peptides was reported for the sex pheromones of basidiomycete yeasts7.This type of post-translational modification is now recognized as quite common and is important for peptide and protein function8.Because the modification of tryptophan markedly alters the hydrophobicity and conformation of the unmodified peptide precursor,the elucidation of the pheromone structure will permit investigations of pheromone interactions with the cognate ComP receptors9 and the determinants of specificity in these interactions.Although several secondary metabolites of isoprenylated tryptophan derivatives are known,the ring structure we determined for the isoprenyl-modified tryptophan residue in the ComX pheromone is a unique post-translational modification.
Other ComX pheromones—such as ComX168 and ComXRO-C-2,produced by strains 168 and RO-C-2 of B.subtilis,respectively—are predicted to be modified by farnesyl groups,based on the mass of their modifications1,2.Given the role of ComQ in the isoprenylation of each ComX variant5,the structures of these pheromones may be similar to that described here.Early work on the farnesyl modification of the C-terminal cysteine in peptides was reported for the sex pheromones of basidiomycete yeasts7.This type of post-translational modification is now recognized as quite common and is important for peptide and protein function8.Because the modification of tryptophan markedly alters the hydrophobicity and conformation of the unmodified peptide precursor,the elucidation of the pheromone structure will permit investigations of pheromone interactions with the cognate ComP receptors9 and the determinants of specificity in these interactions.Although several secondary metabolites of isoprenylated tryptophan derivatives are known,the ring structure we determined for the isoprenyl-modified tryptophan residue in the ComX pheromone is a unique post-translational modification.
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