Tell me what is wrong with it?还是Tell me what the matter is with it?为什么?
What is wrong with it?
What is the matter with it?
如Is there anything wrong with you?
=Is there anything the matter with you?
再答： 引导词做主语就不用改的。 如Do you know who will come? I found what had happened to him. The teacher told me which book belonged to me.(which book 是从句主语） 这种结构在主语从句，表语从句中也是如此。也包括特殊疑问句的。 Who will come to help me?