“别放弃自己”用英语怎么说?是 don't give up on yourself 还是don't give up yo

“别放弃自己”用英语怎么说?是 don't give up on yourself 还是don't give up yourself?
这个on在什么情况下要加到give up后面?什么时候不加?如果加,加什么词性的单词?（我英语不好）