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英语翻译
Our study also addressed the role of extrinsic in-
nervation in postprandial absorption.The study was
designed to determine whether extrinsic innervation
plays a role in mediating postprandial augmenta-
tion in net absorptions.Net ileal absorption of glu-
cose and glutamine in the early postprandial period
was decreased.These decreases in absorption were
not a nonspecific global event,because there was no
postprandial effect on absorption of oleic acid or taur-
ocholate at any time point.Also,there were no gross
changes in transit after feeding that might explain a
decrease in absorption.In addition,although we did
not evaluate intestinal morphology in this experi-
ment,we have shown previously that gross mucosal
morphology does not change with this preparation.
Our previous work and that of others have re-
peatedly shown a marked weight loss after in situ
neural isolation(extrinsic denervation)of the jeju-
noileum
and after jejunoileal autotransplanta-
tion.23,24 The primary cause or causes of this weight
loss have remained elusive.Multiple studies of net
absorptive function in the whole dog and specifically
in jejunum17,25 and ileum18,26 have shown statisti-
cally significant although relatively minor decreases
on baseline absorption during fasting that do not
appear great enough alone to explain either the pro-
fuse watery diarrhea or the weight loss that are
soprominent in the first 2 to 3 weeks after these models
of small bowel autotransplantation.The decrease in
net absorption of the simple solutes(glucose,gluta-
mine)in the early postprandial period may help to
explain these previous observations.Also of interest is
the finding that this postprandial decrease is transient.
Early postprandial net absorption had returned to
normal when measured at 12 weeks after extrinsic
denervation,a time when the watery diarrhea had
also resolved and the dogs had regained the weight
they lost in the early postoperative period.This
postprandial decrease in net absorption may have
translational importance in the field of clinical SBT.
Weight loss and diarrhea occur after SBT in humans,
and the mechanism(s)remains largely unknown
Our study also addressed the role of extrinsic in-
nervation in postprandial absorption.The study was
designed to determine whether extrinsic innervation
plays a role in mediating postprandial augmenta-
tion in net absorptions.Net ileal absorption of glu-
cose and glutamine in the early postprandial period
was decreased.These decreases in absorption were
not a nonspecific global event,because there was no
postprandial effect on absorption of oleic acid or taur-
ocholate at any time point.Also,there were no gross
changes in transit after feeding that might explain a
decrease in absorption.In addition,although we did
not evaluate intestinal morphology in this experi-
ment,we have shown previously that gross mucosal
morphology does not change with this preparation.
Our previous work and that of others have re-
peatedly shown a marked weight loss after in situ
neural isolation(extrinsic denervation)of the jeju-
noileum
and after jejunoileal autotransplanta-
tion.23,24 The primary cause or causes of this weight
loss have remained elusive.Multiple studies of net
absorptive function in the whole dog and specifically
in jejunum17,25 and ileum18,26 have shown statisti-
cally significant although relatively minor decreases
on baseline absorption during fasting that do not
appear great enough alone to explain either the pro-
fuse watery diarrhea or the weight loss that are
soprominent in the first 2 to 3 weeks after these models
of small bowel autotransplantation.The decrease in
net absorption of the simple solutes(glucose,gluta-
mine)in the early postprandial period may help to
explain these previous observations.Also of interest is
the finding that this postprandial decrease is transient.
Early postprandial net absorption had returned to
normal when measured at 12 weeks after extrinsic
denervation,a time when the watery diarrhea had
also resolved and the dogs had regained the weight
they lost in the early postoperative period.This
postprandial decrease in net absorption may have
translational importance in the field of clinical SBT.
Weight loss and diarrhea occur after SBT in humans,
and the mechanism(s)remains largely unknown
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