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As recently as 2002,most cases of primary membranous nephropathy (MN),a relatively common cause of nephrotic syndrome in adults,were considered idiopathic.We now recognize that MN is an organ-specific autoimmune disease in which circulating autoantibodies bind to an intrinsic antigen on glomerular podocytes and form deposits of immune complexes in situ in the glomerular capillary walls.
As recently as 2002,most cases of primary membranous nephropathy (MN),a relatively common cause of nephrotic syndrome in adults,were considered idiopathic.We now recognize that MN is an organ-specific autoimmune disease in which circulating autoantibodies bind to an intrinsic antigen on glomerular podocytes and form deposits of immune complexes in situ in the glomerular capillary walls.
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