问题描述：
下句中Itch-mediated 和Itch?生物学文献中的.网上都查过了,好像都不合适.
原句是In contrast to TNFa plus cycloheximide no cFLIP degradation is observed suggesting a different apoptosis pathway in which the Itch-mediated cFLIP degradation and predominantly caspase-8 activation is not involved.和It has been reported that JNK directly activates the E3 ubiquitin ligase Itch which induces proteasomal processing of cFLIP
原句是In contrast to TNFa plus cycloheximide no cFLIP degradation is observed suggesting a different apoptosis pathway in which the Itch-mediated cFLIP degradation and predominantly caspase-8 activation is not involved.和It has been reported that JNK directly activates the E3 ubiquitin ligase Itch which induces proteasomal processing of cFLIP
问题解答：
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